Conferences APA. Even as antidepressants improve mood, they can worsen sleep-and poor sleep is both a symptom and a cause of depression. Even as they improve mood they can worsen sleep, and poor sleep is both a symptom and a cause of depression. A sedating antidepressant makes sense for patients with insomnia and depression, but just as important is how that antidepressant affects sleep quality. Mirtazapine and trazodone are two antidepressants that help patients fall asleep and improve their sleep architecture. Trazodone also has limitations.
The antidepressant and antipsychotic drugs are a set of agents with a wide range of different pharmacologic effects. Many of these pharmacologic effects impact sleep-wake function. Depending on the time of day of administration, the pharmacokinetics of the drug, the dose of the drug, and the context, some of these effects may be therapeutic and some may be adverse effects. For example, when administered at bedtime to a patient with sleep difficulty, the sleep promoting effects of an antipsychotic medication can be therapeutic. However, if that medication is administered in the morning or if the combination of dosage and half-life of the medication result in next-day effects, the sleep promotion associated with this medication can be problematic.
ANN M. Related Editorial. The use of antipsychotic medications entails a difficult trade-off between the benefit of alleviating psychotic symptoms and the risk of troubling, sometimes life-shortening adverse effects. There is more variability among specific antipsychotic medications than there is between the first- and second-generation antipsychotic classes.
Antipsychotic medications can reduce or relieve symptoms of psychosis, such as delusions false beliefs and hallucinations seeing or hearing something that is not there. Formerly known as major tranquilizers and neuroleptics, antipsychotic medications are the main class of drugs used to treat people with schizophrenia. Other uses of antipsychotics include stabilizing moods in bipolar disorder, reducing anxiety in anxiety disorders and reducing tics in Tourette syndrome. Antipsychotic medications can help to calm and clear confusion in a person with acute psychosis within hours or days, but they can take up to four or six weeks to reach their full effect.