Sperm increased hds

Language: English French. However, data on what exactly this parameter reveals, its relevance and usefulness are contradictory. The objective of this study was thus to answer the question of whether HDS is a relevant and reliable parameter to be taken into account? HDS correlates poorly with most tests that focus specifically on the level of maturity of the sperm nucleus. It shows the potency, consistency and limitations of each test and the care that must be taken in their interpretation. Optimal nuclear sperm condensation is one of the major issues in the male germ cell differentiation program and, to achieve this, mammalian sperm go through a complex process during spermiogenesis and post-testicular maturation for recent reviews, see: [ 1 — 3 ].
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About SCSA Diagnostics

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Could high DNA stainability (HDS) be a valuable indicator of sperm nuclear integrity?

Bungum, P. Humaidan, M. Spano, K. Jepson, L. Bungum, A. Reproductive outcome parameters were biochemical pregnancy BP , clinical pregnancy CP and delivery D. Disturbances in this process may have a negative impact on male fertility as the highly organized and compact sperm chromatin is known to have a crucial influence on the fertilizing process Twigg et al.
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Could high DNA stainability (HDS) be a valuable indicator of sperm nuclear integrity?

A low number of patients received IUI with low success rate, and statistical analysis was therefore not performed. Couples diagnosed with male infertility had a significantly higher level of DFI compared to couples with idiopathic fertility. Sperm head morphology showed low but significant correlations with the SCSA variables. During the last steps of spermatogenesis, the sperm nucleus condenses, and the characteristic shape of the sperm head is formed. The result is a highly packaged chromatin structure, with apparently no DNA transcription or RNA translation taking place.
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Such patients are counseled to try ICSI fertilization. Menezo, one of the leading infertility specialists in France, states, "a strict check of sperm is mandatory before all assisted reproduction treatment. Moderate to high DNA fragmentation levels found within these red fluorescing sperm are likely beyond the DNA repair capacity of the egg. Selecting sperm for ICSI—by high magnification microscopy It has been shown that sperm appearing as morphologically normal with the use of the microscopes typically used in an ICSI procedure may in fact carry various structural abnormalities that can only be detected with the use of a higher magnification microscope Bartoov et al
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